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Induction of 8,5′-Cyclo-2′-deoxyadenosine and 8,5′-Cyclo-2′-deoxyguanosine in Isolated DNA by Fenton-type Reagents

Exposure of aqueous solutions of DNA to X- or γ-rays, which induces hydroxyl radical as one of the major reactive oxygen species (ROS), can result in the generation of a battery of single-nucleobase and bulky DNA lesions. These include the (5′R) and (5′S) diastereomers of 8,5′-cyclo-2′-deoxyadenosin...

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Detalhes bibliográficos
Main Authors: Guerrero, Candace R., Wang, Jin, Wang, Yinsheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822073/
https://ncbi.nlm.nih.gov/pubmed/23961697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400221w
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