YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity

The role of YAP (Yes associated protein 1 gene) and MRTF-A (myocardin-related transcription factor A), two transcriptional co-activators regulated downstream of GPCRs (G-protein coupled receptors) and RhoA, in growth of glioblastoma cells and in vivo glioblastoma multiforme (GBM) tumor development w...

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Veröffentlicht in:Oncogene
Hauptverfasser: Yu, Olivia M, Benitez, Jorge A, Plouffe, Steven W, Ryback, Daniel, Klein, Andrea, Smith, Jeff, Greenbaum, Jason, Delatte, Benjamin, Rao, Anjana, Guan, Kun-Liang, Furnari, Frank B, Chaim, Olga Meiri, Miyamoto, Shigeki, Brown, Joan Heller
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195840/
https://ncbi.nlm.nih.gov/pubmed/29887596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0301-5
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