Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection

Activation of RhoA, a low molecular-weight G-protein, plays an important role in protecting the heart against ischemic stress. Studies using non-cardiac cells demonstrate that the expression and subsequent secretion of the matricellular protein CCN1 is induced by GPCR agonists that activate RhoA. In...

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Autori principali: Zhao, Xia, Ding, Eric Y., Yu, Olivia, Xiang, Sunny Y., Tan-Sah, Valerie P., Yung, Bryan S., Hedgpeth, Joe, Neubig, Richard R., Lau, Lester F., Brown, Joan Heller, Miyamoto, Shigeki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157956/
https://ncbi.nlm.nih.gov/pubmed/25106095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.07.017
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