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RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes

Cardiac ischemia/reperfusion, loss of blood flow and its subsequent restoration, causes damage to the heart. Oxidative stress from ischemia/reperfusion leads to dysfunction and death of cardiomyocytes, increasing the risk of progression to heart failure. Alterations in mitochondrial dynamics, in par...

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Publicat a:Cell Signal
Autors principals: Brand, Cameron S., Tan, Valerie P., Brown, Joan Heller, Miyamoto, Shigeki
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361616/
https://ncbi.nlm.nih.gov/pubmed/29953931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2018.06.012
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