CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response

Predicting the response and identifying additional targets that will improve the efficacy of chemotherapy is a major goal in cancer research. Through large-scale in vivo and in vitro CRISPR knockout screens in pancreatic ductal adenocarcinoma cells, we identified genes whose genetic deletion or phar...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Szlachta, Karol, Kuscu, Cem, Tufan, Turan, Adair, Sara J., Shang, Stephen, Michaels, Alex D., Mullen, Matthew G., Fischer, Natasha Lopes, Yang, Jiekun, Liu, Limin, Trivedi, Prasad, Stelow, Edward B., Stukenberg, P. Todd, Parsons, J. Thomas, Bauer, Todd W., Adli, Mazhar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189038/
https://ncbi.nlm.nih.gov/pubmed/30323222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06676-2
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