Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer

BACKGROUND: The mutational processes underlying non-coding cancer mutations and their biological significance in tumor evolution are poorly understood. To get better insights into the biological mechanisms of mutational processes in breast cancer, we integrate whole-genome level somatic mutations fr...

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Veröffentlicht in:Genome Biol
Hauptverfasser: Yang, Jiekun, Wei, Xiaolong, Tufan, Turan, Kuscu, Cem, Unlu, Hayrunnisa, Farooq, Saadia, Demirtas, Elif, Paschal, Bryce M., Adli, Mazhar
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223090/
https://ncbi.nlm.nih.gov/pubmed/30404658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1572-4
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