Chemotherapy-induced distal enhancers drive transcriptional programs to maintain the chemoresistant state in ovarian cancer.

Chemoresistance is driven by unique regulatory networks in the genome that are distinct from those necessary for cancer development. Here, we investigate the contribution of enhancer elements to cisplatin resistance in ovarian cancers. Epigenome profiling of multiple cellular models of chemoresistan...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Shang, Stephen, Yang, Jiekun, Jazaeri, Amir A., Duval, Alexander James, Tufan, Turan, Fischer, Natasha Lopes, Benamar, Mouadh, Guessous, Fadila, Lee, Inyoung, Campbell, Robert M., Ebert, Philip J., Abbas, Tarek, Landen, Charles N., Difeo, Analisa, Scacheri, Peter C., Adli, Mazhar
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744966/
https://ncbi.nlm.nih.gov/pubmed/31358529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0215
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