Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma

The cullin-based CRL4-CDT2 ubiquitin ligase is emerging as a master regulator of cell proliferation. CRL4-CDT2 prevents re-initiation of DNA replication during the same cell cycle “rereplication” through targeted degradation of CDT1, SET8 and p21 during S-phase of the cell cycle. We show that CDT2 i...

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Publicat a:EBioMedicine
Autors principals: Benamar, Mouadh, Guessous, Fadila, Du, Kangping, Corbett, Patrick, Obeid, Joseph, Gioeli, Daniel, Slingluff, Craig L., Abbas, Tarek
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006603/
https://ncbi.nlm.nih.gov/pubmed/27333051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.06.023
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