PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4(Cdt2) ubiquitin ligase complex

The DNA polymerase delta processivity factor Proliferating Cell Nuclear Antigen (PCNA) promotes the DNA damage-induced degradation of the replication initiation factor Cdt1 via the CRL4(Cdt2) E3 ubiquitin ligase complex. Here we demonstrate that PCNA promotes the ubiquitylation and degradation of th...

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Main Authors: Abbas, Tarek, Sivaprasad, Uma, Terai, Kenta, Amador, Virginia, Pagano, Michele, Dutta, Anindya
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2008
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546691/
https://ncbi.nlm.nih.gov/pubmed/18794347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1676108
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