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Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

Eukaryotic cell cycle transitions are driven by E3 ubiquitin ligases that catalyze the ubiquitylation and destruction of specific protein targets. For example, the anaphase-promoting complex/cyclosome (APC/C) promotes the exit from mitosis via destruction of securin and mitotic cyclins, whereas CRL1...

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Main Authors: Havens, Courtney G., Walter, Johannes C.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182024/
https://ncbi.nlm.nih.gov/pubmed/21828267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2068611
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