CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis

Monoubiquitination of proliferating cell nuclear antigen (PCNA) is a critical post-translational modification essential for DNA repair by translesion DNA synthesis (TLS). The Rad18 E3 ubiquitin ligase cooperates with the E2 Rad6 to monoubiquitinate PCNA in response to DNA damage. How PCNA is monoubi...

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Bibliographic Details
Main Authors: Terai, Kenta, Abbas, Tarek, Jazaeri, Amir A., Dutta, Anindya
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818832/
https://ncbi.nlm.nih.gov/pubmed/20129063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.12.018
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