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Selective Ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G Ubiquitin-Conjugating Enzymes via the CRL4(Cdt2) Ubiquitin Ligase Complex

CRL4(Cdt2) is a cullin-based E3 ubiquitin ligase that promotes the ubiquitin-dependent proteolysis of various substrates implicated in the control of cell cycle and various DNA metabolic processes such as DNA replication and repair. Substrates for CRL4(Cdt2) E3 ubiquitin ligase include the replicati...

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Detalhes bibliográficos
Main Authors: Shibata, Etsuko, Abbas, Tarek, Huang, Xinhua, Wohlschlegel, James A., Dutta, Anindya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147600/
https://ncbi.nlm.nih.gov/pubmed/21628527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05496-11
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