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CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration

The Cul4-Cdt2 (CRL4(Cdt2)) E3 ubiquitin ligase is a master regulator of cell cycle progression and genome stability. Despite its central role in the degradation of many cell-cycle regulators, e.g. Cdt1, p21 and Pr-Set7/Set8, little is known about the regulation of its activity. We report that Cdt2 i...

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Main Authors: Abbas, Tarek, Mueller, Adam, Shibata, Etsuko, Keaton, Mignon, Rossi, Mario, Dutta, Anindya
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615078/
https://ncbi.nlm.nih.gov/pubmed/23478445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.02.003
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