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CRL4(Cdt2) Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation
PR-Set7/Set8 is a cell cycle-regulated enzyme that monomethylates lysine 20 of histone H4 (H4K20). Set8 and monomethylated H4K20 are virtually undetectable during G1 and S phases of the cell cycle but increase in late S and in G2. We identify CRL4(Cdt2) as the principal E3 ubiquitin ligase responsib...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2966975/ https://ncbi.nlm.nih.gov/pubmed/20932471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.09.014 |
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