CRL4(Cdt2) Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation

PR-Set7/Set8 is a cell cycle-regulated enzyme that monomethylates lysine 20 of histone H4 (H4K20). Set8 and monomethylated H4K20 are virtually undetectable during G1 and S phases of the cell cycle but increase in late S and in G2. We identify CRL4(Cdt2) as the principal E3 ubiquitin ligase responsib...

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Bibliografiske detaljer
Main Authors: Abbas, Tarek, Shibata, Etsuko, Park, Jonghoon, Jha, Sudhakar, Karnani, Neerja, Dutta, Anindya
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966975/
https://ncbi.nlm.nih.gov/pubmed/20932471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.09.014
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