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CRL4(Cdt2) E3 Ubiquitin Ligase and Proliferating Cell Nuclear Antigen (PCNA) Cooperate to Degrade Thymine DNA Glycosylase in S Phase

Thymine DNA glycosylase (TDG) is an essential enzyme playing multiple roles in base excision repair, transcription regulation, and DNA demethylation. TDG mediates the cytotoxicity of the anti-cancer chemotherapeutic drug 5-fluorouracil (5-FU) by prolonging S phase, generating DNA strand breaks, and...

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Bibliografiske detaljer
Main Authors: Shibata, Etsuko, Dar, Ashraf, Dutta, Anindya
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132804/
https://ncbi.nlm.nih.gov/pubmed/24962565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.574210
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