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CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
Monoubiquitination of proliferating cell nuclear antigen (PCNA) is a critical post-translational modification essential for DNA repair by translesion DNA synthesis (TLS). The Rad18 E3 ubiquitin ligase cooperates with the E2 Rad6 to monoubiquitinate PCNA in response to DNA damage. How PCNA is monoubi...
Gorde:
| Egile Nagusiak: | , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2010
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818832/ https://ncbi.nlm.nih.gov/pubmed/20129063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.12.018 |
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