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Direct binding of Cdt2 to PCNA is important for targeting the CRL4(Cdt2) E3 ligase activity to Cdt1
The CRL4(Cdt2) ubiquitin ligase complex is an essential regulator of cell-cycle progression and genome stability, ubiquitinating substrates such as p21, Set8, and Cdt1, via a display of substrate degrons on proliferating cell nuclear antigens (PCNAs). Here, we examine the hierarchy of the ligase and...
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| Udgivet i: | Life Sci Alliance |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Life Science Alliance LLC
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6312923/ https://ncbi.nlm.nih.gov/pubmed/30623174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800238 |
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