Direct binding of Cdt2 to PCNA is important for targeting the CRL4(Cdt2) E3 ligase activity to Cdt1

The CRL4(Cdt2) ubiquitin ligase complex is an essential regulator of cell-cycle progression and genome stability, ubiquitinating substrates such as p21, Set8, and Cdt1, via a display of substrate degrons on proliferating cell nuclear antigens (PCNAs). Here, we examine the hierarchy of the ligase and...

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Veröffentlicht in:Life Sci Alliance
Hauptverfasser: Hayashi, Akiyo, Giakoumakis, Nickolaos Nikiforos, Heidebrecht, Tatjana, Ishii, Takashi, Panagopoulos, Andreas, Caillat, Christophe, Takahara, Michiyo, Hibbert, Richard G, Suenaga, Naohiro, Stadnik-Spiewak, Magda, Takahashi, Tatsuro, Shiomi, Yasushi, Taraviras, Stavros, von Castelmur, Eleonore, Lygerou, Zoi, Perrakis, Anastassis, Nishitani, Hideo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Life Science Alliance LLC 2018
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312923/
https://ncbi.nlm.nih.gov/pubmed/30623174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800238
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