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CRL4(CDT2) Targets CHK1 for PCNA-Independent Destruction

CDT2 targets proteins involved in replication licensing (CDT1), cell cycle control (p21), and chromatin modification (SET8) for destruction by the CUL4-based E3 ligase (CRL4). CRL4(CDT2) recruits these substrates through interactions with chromatin-bound PCNA and ubiquitinates them exclusively on ch...

詳細記述

保存先:
書誌詳細
主要な著者: Huh, Jiwon, Piwnica-Worms, Helen
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554108/
https://ncbi.nlm.nih.gov/pubmed/23109433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00847-12
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