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DDB1 Targets Chk1 to the Cul4 E3 Ligase Complex in Normal Cycling Cells and in Cells Experiencing Replication Stress
The Chk1 protein kinase preserves genome integrity in normal proliferating cells and in cells experiencing replicative- and genotoxic-stress. Chk1 is currently being targeted in anti-cancer regimens. Here we identify damaged DNA-binding protein 1 (DDB1) as a novel Chk1 interacting protein. DDB1 is p...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2009
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776040/ https://ncbi.nlm.nih.gov/pubmed/19276361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3382 |
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