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CRL4(CDT2) Targets CHK1 for PCNA-Independent Destruction
CDT2 targets proteins involved in replication licensing (CDT1), cell cycle control (p21), and chromatin modification (SET8) for destruction by the CUL4-based E3 ligase (CRL4). CRL4(CDT2) recruits these substrates through interactions with chromatin-bound PCNA and ubiquitinates them exclusively on ch...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554108/ https://ncbi.nlm.nih.gov/pubmed/23109433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00847-12 |
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