Two Different Replication Factor C Proteins, Ctf18 and RFC1, Separately Control PCNA-CRL4(Cdt2)-Mediated Cdt1 Proteolysis during S Phase and following UV Irradiation

Recent work identified the E3 ubiquitin ligase CRL4(Cdt2) as mediating the timely degradation of Cdt1 during DNA replication and following DNA damage. In both cases, proliferating cell nuclear antigen (PCNA) loaded on chromatin mediates the CRL4(Cdt2)-dependent proteolysis of Cdt1. Here, we demonstr...

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Hauptverfasser: Shiomi, Yasushi, Hayashi, Akiyo, Ishii, Takashi, Shinmyozu, Kaori, Nakayama, Jun-ichi, Sugasawa, Kaoru, Nishitani, Hideo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372265/
https://ncbi.nlm.nih.gov/pubmed/22493068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06506-11
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