Checkpoint Kinase ATR Phosphorylates Cdt2, a Substrate Receptor of CRL4 Ubiquitin Ligase, and Promotes the Degradation of Cdt1 following UV Irradiation

The DNA replication-licensing factor Cdt1 is present during the G1 phase of the cell cycle. When cells initiate S phase or are UV-irradiated, Cdt1 is recruited to chromatin-bound PCNA and ubiquitinated by CRL4(Cdt2) for degradation. In both situations, the substrate-recognizing subunit Cdt2 is detec...

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Detalhes bibliográficos
Main Authors: Sakaguchi, Hiroki, Takami, Toshihiro, Yasutani, Yoshinori, Maeda, Takeshi, Morino, Masayuki, Ishii, Takashi, Shiomi, Yasushi, Nishitani, Hideo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460910/
https://ncbi.nlm.nih.gov/pubmed/23029527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046480
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