Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase

Cdt1 is rapidly degraded by CRL4(Cdt2) E3 ubiquitin ligase after UV (UV) irradiation. Previous reports revealed that the nucleotide excision repair (NER) pathway is responsible for the rapid Cdt1-proteolysis. Here, we show that mismatch repair (MMR) proteins are also involved in the degradation of C...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Tanaka, Miyuki, Takahara, Michiyo, Nukina, Kohei, Hayashi, Akiyo, Sakai, Wataru, Sugasawa, Kaoru, Shiomi, Yasushi, Nishitani, Hideo
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
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Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397274/
https://ncbi.nlm.nih.gov/pubmed/28278049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1295179
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