Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase

Cdt1 is rapidly degraded by CRL4(Cdt2) E3 ubiquitin ligase after UV (UV) irradiation. Previous reports revealed that the nucleotide excision repair (NER) pathway is responsible for the rapid Cdt1-proteolysis. Here, we show that mismatch repair (MMR) proteins are also involved in the degradation of C...

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Publicado en:Cell Cycle
Main Authors: Tanaka, Miyuki, Takahara, Michiyo, Nukina, Kohei, Hayashi, Akiyo, Sakai, Wataru, Sugasawa, Kaoru, Shiomi, Yasushi, Nishitani, Hideo
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397274/
https://ncbi.nlm.nih.gov/pubmed/28278049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1295179
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