Evolution on the Biophysical Fitness Landscape of an RNA Virus

Viral evolutionary pathways are determined by the fitness landscape, which maps viral genotype to fitness. However, a quantitative description of the landscape and the evolutionary forces on it remain elusive. Here, we apply a biophysical fitness model based on capsid folding stability and antibody...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Main Authors: Rotem, Assaf, Serohijos, Adrian W R, Chang, Connie B, Wolfe, Joshua T, Fischer, Audrey E, Mehoke, Thomas S, Zhang, Huidan, Tao, Ye, Lloyd Ung, W, Choi, Jeong-Mo, Rodrigues, João V, Kolawole, Abimbola O, Koehler, Stephan A, Wu, Susan, Thielen, Peter M, Cui, Naiwen, Demirev, Plamen A, Giacobbi, Nicholas S, Julian, Timothy R, Schwab, Kellogg, Lin, Jeffrey S, Smith, Thomas J, Pipas, James M, Wobus, Christiane E, Feldman, Andrew B, Weitz, David A, Shakhnovich, Eugene I
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Discoveries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188569/
https://ncbi.nlm.nih.gov/pubmed/29955873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msy131
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