Evolution on the Biophysical Fitness Landscape of an RNA Virus

Viral evolutionary pathways are determined by the fitness landscape, which maps viral genotype to fitness. However, a quantitative description of the landscape and the evolutionary forces on it remain elusive. Here, we apply a biophysical fitness model based on capsid folding stability and antibody...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Biol Evol
Prif Awduron: Rotem, Assaf, Serohijos, Adrian W R, Chang, Connie B, Wolfe, Joshua T, Fischer, Audrey E, Mehoke, Thomas S, Zhang, Huidan, Tao, Ye, Lloyd Ung, W, Choi, Jeong-Mo, Rodrigues, João V, Kolawole, Abimbola O, Koehler, Stephan A, Wu, Susan, Thielen, Peter M, Cui, Naiwen, Demirev, Plamen A, Giacobbi, Nicholas S, Julian, Timothy R, Schwab, Kellogg, Lin, Jeffrey S, Smith, Thomas J, Pipas, James M, Wobus, Christiane E, Feldman, Andrew B, Weitz, David A, Shakhnovich, Eugene I
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2018
Pynciau:
Discoveries
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188569/
https://ncbi.nlm.nih.gov/pubmed/29955873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msy131
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