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Contribution of Selection for Protein Folding Stability in Shaping the Patterns of Polymorphisms in Coding Regions

The patterns of polymorphisms in genomes are imprints of the evolutionary forces at play in nature. In particular, polymorphisms have been extensively used to infer the fitness effects of mutations and their dynamics of fixation. However, the role and contribution of molecular biophysics to these ob...

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Autors principals: Serohijos, Adrian W.R., Shakhnovich, Eugene I.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879451/
https://ncbi.nlm.nih.gov/pubmed/24124208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mst189
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