Protein Quality Control Acts on Folding Intermediates to Shape the Effects of Mutations on Organismal Fitness

What are the molecular properties of proteins that fall on the radar of protein quality control (PQC)? Here we mutate the E. coli’s gene encoding dihydrofolate reductase (DHFR), and replace it with bacterial orthologous genes to determine how components of PQC modulate fitness effects of these genet...

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Hauptverfasser: Bershtein, Shimon, Mu, Wanmeng, Serohijos, Adrian W. R., Zhou, Jingwen, Shakhnovich, Eugene I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545112/
https://ncbi.nlm.nih.gov/pubmed/23219534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.11.004
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