Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in Bacteria

Horizontal gene transfer (HGT) plays a central role in bacterial evolution, yet the molecular and cellular constraints on functional integration of the foreign genes are poorly understood. Here we performed inter-species replacement of the chromosomal folA gene, encoding an essential metabolic enzym...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Bershtein, Shimon, Serohijos, Adrian W. R., Bhattacharyya, Sanchari, Manhart, Michael, Choi, Jeong-Mo, Mu, Wanmeng, Zhou, Jingwen, Shakhnovich, Eugene I.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618355/
https://ncbi.nlm.nih.gov/pubmed/26484862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005612
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