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Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations

Mutations create the genetic diversity on which selective pressures can act, yet also create structural instability in proteins. How, then, is it possible for organisms to ameliorate mutation-induced perturbations of protein stability while maintaining biological fitness and gaining a selective adva...

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Detalhes bibliográficos
Main Authors: Bershtein, Shimon, Wu, Wanmeng, Shakhnovich, Eugene I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323985/
https://ncbi.nlm.nih.gov/pubmed/22411825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118157109
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