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Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations
Mutations create the genetic diversity on which selective pressures can act, yet also create structural instability in proteins. How, then, is it possible for organisms to ameliorate mutation-induced perturbations of protein stability while maintaining biological fitness and gaining a selective adva...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3323985/ https://ncbi.nlm.nih.gov/pubmed/22411825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118157109 |
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