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NAD(+)-dependent synthesis of a 5′-phospho-ADP-ribosylated RNA/DNA cap by RNA 2′-phosphotransferase Tpt1

RNA 2′-phosphotransferase Tpt1 converts an internal RNA 2′-monophosphate to a 2′-OH via a two-step NAD(+)-dependent mechanism in which: (i) the 2′-phosphate attacks the C1″ of NAD(+) to expel nicotinamide and form a 2′-phospho-ADP-ribosylated RNA intermediate; and (ii) the ADP-ribose O2″ attacks the...

詳細記述

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書誌詳細
出版年:Nucleic Acids Res
主要な著者: Munir, Annum, Banerjee, Ankan, Shuman, Stewart
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182162/
https://ncbi.nlm.nih.gov/pubmed/30202863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky792
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