Загрузка...
Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO(4) recognition and ADP-ribosylation
Tpt1 is an essential agent of fungal tRNA splicing that removes the 2′-PO(4) at the splice junction generated by fungal tRNA ligase. Tpt1 catalyzes a unique two-step reaction whereby the 2′-PO(4) attacks NAD(+) to form an RNA-2′-phospho-ADP-ribosyl intermediate that undergoes transesterification to...
Сохранить в:
| Опубликовано в: : | Nat Commun |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2019
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6333775/ https://ncbi.nlm.nih.gov/pubmed/30644400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08211-9 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|