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Activity and substrate specificity of Candida, Aspergillus, and Coccidioides Tpt1: essential tRNA splicing enzymes and potential antifungal targets
The enzyme Tpt1 is an essential agent of fungal tRNA splicing that removes an internal RNA 2′-PO(4) generated by fungal tRNA ligase. Tpt1 performs a two-step reaction in which: (i) the 2′-PO(4) attacks NAD(+) to form an RNA-2′-phospho-(ADP-ribose) intermediate; and (ii) transesterification of the AD...
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| Publicado no: | RNA |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8051265/ https://ncbi.nlm.nih.gov/pubmed/33509912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.078660.120 |
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