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Substrate analogs that trap the 2′-phospho-ADP-ribosylated RNA intermediate of the Tpt1 (tRNA 2′-phosphotransferase) reaction pathway

The enzyme Tpt1 removes an internal RNA 2′-PO(4) via a two-step reaction in which: (i) the 2′-PO(4) attacks NAD(+) to form an RNA-2′-phospho-(ADP-ribose) intermediate and nicotinamide; and (ii) transesterification of the ADP-ribose O2″ to the RNA 2′-phosphodiester yields 2′-OH RNA and ADP-ribose-1″,...

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Detalhes bibliográficos
Publicado no:RNA
Main Authors: Dantuluri, Swathi, Abdullahu, Leonora, Munir, Annum, Katolik, Adam, Damha, Masad J., Shuman, Stewart
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075268/
https://ncbi.nlm.nih.gov/pubmed/31932322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.074377.119
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