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Targeting histone methyltransferase enhancer of zeste homolog-2 inhibits renal epithelial–mesenchymal transition and attenuates renal fibrosis
Enhancer of zeste homolog-2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types. Its role in renal epithelial–mesenchymal transition (EMT) remains unknown. In this study, we found that EZH2 and H3K27me3 w...
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| Pubblicato in: | FASEB J |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Federation of American Societies for Experimental Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6181636/ https://ncbi.nlm.nih.gov/pubmed/29775417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800237R |
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