Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis

In this study, we examined the effect of MC1568, a selective class IIa histone deacetylase (HDAC) inhibitor, on the development and progression of renal fibrosis in a murine model of renal fibrosis induced by unilateral ureteral obstruction (UUO). All 4 class IIa HDAC isoforms, in particular HDAC4,...

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Vydáno v:FASEB J
Hlavní autoři: Xiong, Chongxiang, Guan, Yingjie, Zhou, Xiaoxu, Liu, Lirong, Zhuang, Michelle A., Zhang, Wei, Zhang, Yunhe, Masucci, Monica V., Bayliss, George, Zhao, Ting C., Zhuang, Shougang
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2019
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593874/
https://ncbi.nlm.nih.gov/pubmed/30951378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801067RR
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