Targeting histone methyltransferase enhancer of zeste homolog-2 inhibits renal epithelial–mesenchymal transition and attenuates renal fibrosis

Enhancer of zeste homolog-2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types. Its role in renal epithelial–mesenchymal transition (EMT) remains unknown. In this study, we found that EZH2 and H3K27me3 w...

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Publicado en:FASEB J
Autores principales: Zhou, Xiaoxu, Xiong, Chongxiang, Tolbert, Evelyn, Zhao, Ting C., Bayliss, George, Zhuang, Shougang
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2018
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181636/
https://ncbi.nlm.nih.gov/pubmed/29775417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800237R
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