Targeting histone methyltransferase enhancer of zeste homolog-2 inhibits renal epithelial–mesenchymal transition and attenuates renal fibrosis

Enhancer of zeste homolog-2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types. Its role in renal epithelial–mesenchymal transition (EMT) remains unknown. In this study, we found that EZH2 and H3K27me3 w...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Zhou, Xiaoxu, Xiong, Chongxiang, Tolbert, Evelyn, Zhao, Ting C., Bayliss, George, Zhuang, Shougang
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181636/
https://ncbi.nlm.nih.gov/pubmed/29775417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800237R
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