Humanized GPIbα–von Willebrand factor interaction in the mouse

The interaction of platelet glycoprotein Ibα (GPIbα) with von Willebrand factor (VWF) initiates hemostasis after vascular injury and also contributes to pathological thrombosis. GPIbα binding to the VWF A1 domain (VWFA1) is a target for antithrombotic intervention, but attempts to develop pharmacolo...

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Vydáno v:Blood Adv
Hlavní autoři: Kanaji, Sachiko, Orje, Jennifer N., Kanaji, Taisuke, Kamikubo, Yuichi, Morodomi, Yosuke, Chen, Yunfeng, Zarpellon, Alessandro, Eberhardt, Jerome, Forli, Stefano, Fahs, Scot A., Sood, Rashmi, Haberichter, Sandra L., Montgomery, Robert R., Ruggeri, Zaverio M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177644/
https://ncbi.nlm.nih.gov/pubmed/30287479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018023507
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