Humanized GPIbα–von Willebrand factor interaction in the mouse

The interaction of platelet glycoprotein Ibα (GPIbα) with von Willebrand factor (VWF) initiates hemostasis after vascular injury and also contributes to pathological thrombosis. GPIbα binding to the VWF A1 domain (VWFA1) is a target for antithrombotic intervention, but attempts to develop pharmacolo...

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Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: Kanaji, Sachiko, Orje, Jennifer N., Kanaji, Taisuke, Kamikubo, Yuichi, Morodomi, Yosuke, Chen, Yunfeng, Zarpellon, Alessandro, Eberhardt, Jerome, Forli, Stefano, Fahs, Scot A., Sood, Rashmi, Haberichter, Sandra L., Montgomery, Robert R., Ruggeri, Zaverio M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177644/
https://ncbi.nlm.nih.gov/pubmed/30287479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018023507
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