Humanized GPIbα–von Willebrand factor interaction in the mouse

The interaction of platelet glycoprotein Ibα (GPIbα) with von Willebrand factor (VWF) initiates hemostasis after vascular injury and also contributes to pathological thrombosis. GPIbα binding to the VWF A1 domain (VWFA1) is a target for antithrombotic intervention, but attempts to develop pharmacolo...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Kanaji, Sachiko, Orje, Jennifer N., Kanaji, Taisuke, Kamikubo, Yuichi, Morodomi, Yosuke, Chen, Yunfeng, Zarpellon, Alessandro, Eberhardt, Jerome, Forli, Stefano, Fahs, Scot A., Sood, Rashmi, Haberichter, Sandra L., Montgomery, Robert R., Ruggeri, Zaverio M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177644/
https://ncbi.nlm.nih.gov/pubmed/30287479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018023507
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