von Willebrand factor variant D1472H has no effect in mice with humanized VWF-platelet interactions

The von Willebrand factor ristocetin cofactor activity assay (VWF:RCo) is used for diagnosis of von Willebrand disease (VWD) because of its ability to evaluate VWF binding to platelets. VWF sequence variant p.D1472H is associated with lower VWF:RCo levels in the absence of associated bleeding sympto...

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Pubblicato in:Blood Adv
Autori principali: Lohmeier, Hannah K., Slobodianuk, Tricia L., Kanaji, Sachiko, Haberichter, Sandra L., Montgomery, Robert R., Flood, Veronica H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Thrombosis and Hemostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479953/
https://ncbi.nlm.nih.gov/pubmed/32870970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002629
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