Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2

The Gcn5 histone acetyltransferase (HAT) subunit of the SAGA transcriptional coactivator complex catalyzes acetylation of histone H3 and H2B N-terminal tails, posttranslational modifications associated with gene activation. Binding of the SAGA subunit partner Ada2 to Gcn5 activates Gcn5’s intrinsica...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sun, Jian, Paduch, Marcin, Kim, Sang-Ah, Kramer, Ryan M., Barrios, Adam F., Lu, Vincent, Luke, Judy, Usatyuk, Svitlana, Kossiakoff, Anthony A., Tan, Song
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176591/
https://ncbi.nlm.nih.gov/pubmed/30224453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805343115
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