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Reviving oncogenic addiction to MET bypassed by BRAF (G469A) mutation

Cancer clonal evolution is based on accrual of driving genetic alterations that are expected to cooperate and progressively increase malignancy. Little is known on whether any genetic alteration can hinder the oncogenic function of a coexisting alteration, so that therapeutic targeting of the one ca...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Virzì, Anna Rita, Gentile, Alessandra, Benvenuti, Silvia, Comoglio, Paolo M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176587/
https://ncbi.nlm.nih.gov/pubmed/30224486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721147115
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