A point mutation in the MET oncogene abrogates metastasis without affecting transformation

The MET oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor/scatter factor (HGF), known to stimulate invasive growth of epithelial cells. MET is overexpressed in a significant percentage of human cancers and is amplified during the transition between primary tumors and metasta...

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Autors principals: Giordano, Silvia, Bardelli, Alberto, Zhen, Zhu, Menard, Sylvie, Ponzetto, Carola, Comoglio, Paolo M.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1997
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC28399/
https://ncbi.nlm.nih.gov/pubmed/9391119
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