C(16)-ceramide is a natural regulatory ligand of p53 in cellular stress response

Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here we report the mechanism for activation of p53 tumor suppressor by C(16)-ceramide. C(16)-ceramide tightly binds within the p53 DNA-binding domain (K(d) ~ 60 nM), in close vicinity to the Box V...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Fekry, Baharan, Jeffries, Kristen A., Esmaeilniakooshkghazi, Amin, Szulc, Zdzislaw M., Knagge, Kevin J., Kirchner, David R., Horita, David A., Krupenko, Sergey A., Krupenko, Natalia I.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175828/
https://ncbi.nlm.nih.gov/pubmed/30297838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06650-y
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