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C(16)-ceramide is a natural regulatory ligand of p53 in cellular stress response
Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here we report the mechanism for activation of p53 tumor suppressor by C(16)-ceramide. C(16)-ceramide tightly binds within the p53 DNA-binding domain (K(d) ~ 60 nM), in close vicinity to the Box V...
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| Pubblicato in: | Nat Commun |
|---|---|
| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6175828/ https://ncbi.nlm.nih.gov/pubmed/30297838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06650-y |
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