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Folate Stress Induces Apoptosis via p53-dependent de Novo Ceramide Synthesis and Up-regulation of Ceramide Synthase 6

We have investigated the role of ceramide in the cellular adaptation to folate stress induced by Aldh1l1, the enzyme involved in the regulation of folate metabolism. Our previous studies demonstrated that Aldh1l1, similar to folate deficiency, evokes metabolic stress and causes apoptosis in cancer c...

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Hlavní autoři: Hoeferlin, L. Alexis, Fekry, Baharan, Ogretmen, Besim, Krupenko, Sergey A., Krupenko, Natalia I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642331/
https://ncbi.nlm.nih.gov/pubmed/23519469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.461798
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