Folate Stress Induces Apoptosis via p53-dependent de Novo Ceramide Synthesis and Up-regulation of Ceramide Synthase 6

We have investigated the role of ceramide in the cellular adaptation to folate stress induced by Aldh1l1, the enzyme involved in the regulation of folate metabolism. Our previous studies demonstrated that Aldh1l1, similar to folate deficiency, evokes metabolic stress and causes apoptosis in cancer c...

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Bibliografski detalji
Glavni autori: Hoeferlin, L. Alexis, Fekry, Baharan, Ogretmen, Besim, Krupenko, Sergey A., Krupenko, Natalia I.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Lipids
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642331/
https://ncbi.nlm.nih.gov/pubmed/23519469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.461798
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