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Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner

We previously reported that ceramide synthase 6 (CerS6) is elevated in response to folate stress in cancer cells, leading to enhanced production of C(16)-ceramide and apoptosis. Antifolate methotrexate (MTX), a drug commonly used in chemotherapy of several types of cancer, is a strong inhibitor of f...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Fekry, Baharan, Esmaeilniakooshkghazi, Amin, Krupenko, Sergey A., Krupenko, Natalia I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718595/
https://ncbi.nlm.nih.gov/pubmed/26783755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146618
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