CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G(0)/G(1) to S-phase

ALDH1L1 is a folate-metabolizing enzyme abundant in liver and several other tissues. In human cancers and cell lines derived from malignant tumors, the ALDH1L1 gene is commonly silenced through the promoter methylation. It was suggested that ALDH1L1 limits proliferation capacity of the cell and thus...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Khan, Qasim A., Pediaditakis, Peter, Malakhau, Yuryi, Esmaeilniakooshkghazi, Amin, Ashkavand, Zahra, Sereda, Valentin, Krupenko, Natalia I., Krupenko, Sergey A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034817/
https://ncbi.nlm.nih.gov/pubmed/29979702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199699
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