Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS

Hyperpolarized [1‐(13)C] pyruvate MRS can measure cardiac pyruvate dehydrogenase (PDH) flux in vivo through (13)C‐label incorporation into bicarbonate. Using this technology, substrate availability as well as pathology have been shown to modulate PDH flux. Clinical protocols attempt to standardize P...

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Bibliografski detalji
Izdano u:NMR Biomed
Glavni autori: Timm, Kerstin N., Apps, Andrew, Miller, Jack J., Ball, Vicky, Chong, Cher‐Rin, Dodd, Michael S., Tyler, Damian J.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175301/
https://ncbi.nlm.nih.gov/pubmed/30040147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.3992
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